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发酵罐染菌的途径及四大原因

作者:发酵罐 时间:2018-04-13 14:44
抗生素生产一般采用春种发酵,在生产中出现染菌问题是不可轻视的。轻度染菌会影响到本批发酵产品的单位和收率,还可能会为下批生产埋下继续染菌的祸根,严重的染菌除严重影响产品产 信息摘要:
抗生素生产般采用春种 发酵 ,在生产中出现染菌问题是不可轻视的。轻度染菌会影响到本批发酵产品的单位和收率,还可能会为下批生产埋下继续染菌的祸根,严重的染菌除严重影响产品产量和质量外,可能造成生产不能有序进

发酵罐染菌的途径及四大原因

SHENGWUFAJIAOCHANPINYISUIZHEWOGUOSHENGWUYIYAOJISHUDEPENGBOFAZHAN,SHENGWUFAJIAOXITONG(YECHENGWEISHENGWUPEIYANG)XIANGMUYUELAIYUEDUO,RUKANGSHENGSUYUANLIAOYAODEFAJIAO、ANJISUANHEYOUJISUAN(NINGMENGSUAN,RUSUAN)DEFAJIAO、MEIZHIJI、JIAOMUHUODIANFENTANGDEFAJIAO,HAISHIGEZHONGSHENGWUYIMIAO、DONGZHIWUXIBAODEFAJIAODENG,GEZHONGFAJIAOZHIPINYINGRENERSHENG。

、生物发酵罐系统组成:

SHENGWUFAJIAOZHUXITONGSHEBEIHEYUZHIPEITAODEFUZHUXITONGSHEBEI(YICHENGFAJIAOZHICHIXITONG)ZUCHENG。

2、SHENGWUFAJIAOZHUXITONGYOUJUNZHONGBAOCUN、JIEDONGFUHUO、YIZHONG、SHENGWUPEIYANGQI(WEISHENGWUFAJIAOGUAN)JIQIZHICHIKONGZHIXITONG、PEIYANGJIDEPEIZHIYUMIEJUNYIJISHUSONGXITONGZUCHENG;

3、SHENGWUFAJIAOGUANDEFUZHUXITONGSHIYOUYUZHIXIANGGUANLIANDEGONGYIYONGSHUIXITONG(CHUNHUAYONGSHUIJIZHUSHEYONGSHUI)、WUJUNYASUOQITIXITONG(KONGQI,DANQI,CO2QITIDENG)、GUYEFENLIXITONG(RULIXINFENLI、MOGUOLV、BANKUANGGUOLVDENG)、FAJIAOYEDESHOUJIXITONG、FAJIAOYEDEZHUCUNYULENGZANGDENGZUCHENG。

二、生物发酵罐的典型工艺流程:

SHENGWUFAJIAODEGUOCHENGSHIZUSHEJIDUOXIANG、DUOZUFEN、FEIXIANXINGDESHENGWUHUAXUEFANYING,YESHIZUQUNTIXINGDESHENGWUSHENGZHANGGUOCHENG,SHIRENMENBAYUXIANXUANDINGDEWEISHENGWUHUODONGZHIWUXIBAOZAIZUMIBIDEXITONGZHONGANQISHENGZHANGGUILVYUSHENGZHANGFAYUTIAOJIANDEDAIXIEGUOCHENG。

SHENGWUFAJIAOGUANDECAOZUOSHUNXULIUCHENGJIANSHU:

1、YOUZHIJUNZHONGDEYULIANG-JINGSHENGWUYAOCHUANGZAIPEIYANGQILIJINXINGYUZHONG,PEIYANG、SHAIXUANYOULIANGJUNZHONGJINXINGHUOHUA。

水果拉霸多人版 2、JINXINGPEIYANGJIDEPEIZHI

3、FAJIAOGUANJIFUZHUXITONGDENGXUANGOUYUANZHUANG

4、JINXINGHUODUOKUOPEI

5、JINRUSHENGCHANGUANJINXINGCHANWUHECHENG

三、生物发酵工程介绍:

1.BENXILIEFAJIAOXITONGJICHENGANZHUANGZAIGECAOZUOPINGTAISHANG,ZHUYAOYOUZHONGZIGUAN、ERZHONGZIGUAN、FAJIAOGUANJIGUANDAO、KONGZHIXITONGZUCHENG。

2.FAJIAOGUANJIZHONGZIGUANCAIYONGDINGBUJIXIEJIAOBANXITONG,JIAOBANZHUANSUKESHIXIANWUBIANSUKEDIAO 。

水果拉霸多人版 3.KEZAIXIANJIANCEFAJIAOWENDU、GUANYA、PH、DO、PAOMOYEWEI、TONGQILIULIANGDENGCANSHU,KEGENJUKEHUXUYAOSHIXIANGUANYA、JIAOBAN、BULIAODENGZIDONGHUAKONGZHI。

4.KESHIXIANSANZHANGHUGUANLI、CAOZUOSHUJUZIDONGJILU、CAOZUOJILUZIDONGJILU、ZIDONGBAOJING、LISHISHUJUCHAXUN、BAOJINGCHAXUN、SHENGCHENGPIBAOBIAO、SHUJUZHUANYIHEBEIFEN、ZAIXIANDAYINDENGGONGNENG 。

水果拉霸多人版 5.RUDONGBENGZIDONGBUSUAN、BUJIAN、BULIAOJIBUXIAOPAOJI。

6.YIZHONG、QUYANG、JINQI、JIEZHONG、FANGLIAOCAIYONGSHOUDONGKONGZHI

水果拉霸多人版 7.CIPQINGXI、YEWEIJILIANGKEXUANZIDONG/BANZIDONGKONGZHI

水果拉霸多人版 8.PLC/DCSKONGZHIXITONG,CAIYONGJICHENGKONGZHI,CHUMOXIANSHICAOZUOJIEMIAN

9.ZAIWEIMIEJUNSIP,ANQUANKEKAO,TESHUJIXIEMIFENG,SHICHUANGGUANCHAQINGXI,DUOXINGSHIJIEZHONGFANGSHI,MEIGUANDAFANG,CHAIZHUANGJIANBIAN

10、.GAIXILIECHANPINSHIYONGYUFAJIAOCHANPINDESHIYANSHI、XIAOSHI、ZHONGSHI、JIDAGUIMOGONGYEHUASHENGCHAN;SHIYONGYUWEISHENGWUFAJIAO、XIJUNLEIRENYONGYIMIAO、ZHENJUNLEICHANPINFAJIAO、YANYANGJUNFAJIAO、JIYINGONGCHENGJUNDEFAJIAO,DONGWUYIMIAO,ZHIWUXIBAOPEIYANGDENGLINGYU。

水果拉霸多人版 WOGONGSIZHUANYECONGSHINIANGJIUPEITAOSHEBEILINGYUCHANPINYANFA,CHANPINYOUFAJIAOGUAN、PUTAOJIUFAJIAOGUAN、GUOJIUFAJIAOGUAN、BUXIUGANGCHUGUAN、BAIJIUCHUGUAN、BAOWENLENGDONGGUAN、QUANZIDONGFAJIAOKONGWENXITONGDENGGELEIBUXIUGANGGUAN。

 

发酵罐染菌的途径及四大原因

抗生素生产般采用春种发酵,在生产中出现染菌问题是不可轻视的。轻度染菌会影响到本批发酵产品的单位和收率,还可能会为下批生产埋下继续染菌的祸根,严重的染菌除严重影响产品产量和质量外,可能造成生产不能有序进行或无法进行。尤其是发酵罐处在发酵的末阶段,其染菌直接影响到产品优劣和得率,染菌的途径也很多,笔者在深入线实践的过程中总结了些经验,对于预防发酵罐染菌有定的帮助。下面结合实际生产对抗生素不锈钢发酵罐水果拉霸多人版染菌原因从物料、设备、蒸汽(空气)和人为因素等方面作以分析。

1.1 WULIAOZAICUNFANGZHONGBIANXING YOUYUKUFANGTIAOJIANSUOXIAN,WULIAOZAICUNFANGZHONGHUISHOUDAOJIYA、SHOUCHAOERJIEKUAI,ZHEIXIEKUAIZHUANGGUTIWUZAIXIAODUDANGZHONGZHENGQINANYICHUANTOU,CONGERYOUKENENGRANJUN。

RUOGOURUDEWULIAOLIDUTAIDA(RUYUMIFENZHONGCHANZAYOUJIAODUOYUMILI)ZHEIYANGDEPEIYANGJIJINRUFAJIAOGUANZAIMIEJUNSHIHENNANBEIWANQUAN“ZHUSHU”,ZHEIYESHIRANJUNKENENGXINGZHI,DUICIYINGZAIDALIAOBENGHOUZHUANGZHISHAIBANGUOLVQILAIJIEJUE。BIZHEZAISHIJIANZHONGHAIFAXIANYOUYINWULIAOFAMEIERZAOCHENGRANJUNDEQINGKUANG,ZHEIYANGJISHIGAIPIFAJIAOYEYUNZHUANXIAQUYEHUIYINGXIANGCHANPINZHILIANG。

。KONGZHIHESHIDEDALIAOTIJI,DALIAOTIJIGUOXIAO,ZHUANGLIAOXISHUDI,FAJIAOZONGYIXIAJIANG;DALIAOTIJIGUODA,YICHUXIANPAOMODINGGUANYINQIPAOLIAO、RANJUN,ZAOCHENGSUNSHI。

5.2 SHEBEIFANGMIANGUANNEIQINGXIZIXI,BUNENGYOUCANLIAO,BIQIJIECHENGJIAOHUAWU,ERMAIXIARANJUNHUOGEN。

YANMIJIANCHAGUANNEIBUJIANDEMIFENGXING、JINGUXING,FANGZHIJIANXIUBUDAOWEIZAOCHENGDESHENGCHANSHIJIAN,YINGZIXIJIANCHASHEGUANSHIFOUYOUSHENLOU,BIYANZHONGRANJUN。

JIANCHAGEZHIGUAN、FALAN、FAMEN(YOUQISHIKAOGUANFAMEN)DEYANMIDUJITONGCHANGQINGKUANG;JIANCHAFAZUO、FAXINYOUWUJIAOHUAWUHELIAOYECUNZAI,RUOYOUYINGJISHICHEDIQINGCHU,BIZAJUNZISHENG,YINQIRANJUN。

JISHIQINGCHUGUANNEIDANGBANBEIHOU、JIAOBANZHOUDIWAZHIJIA、SHEGUANKAOGUANBIMIANJIQIZHIJIADIBUDENGSIJIAO;GUANWAIZIKONGBULIAOXITONGJINPAIQIBUDAODESIJIAO。

水果拉霸多人版 DINGQIZUOHAOGUANTIYUKAOGUANBUJIAN、ZIKONGBULIAOXITONGHEYIZHONGGUANLUDEYANMIXINGJIANCHAGONGZUO,KEYIBAOZHENGSHIGUANMIEJUN、YIZHONGJIBULIAOGUOCHENGDEWUJUNXING,YEWEICHUNZHONGFAJIAOGUOCHENGZENGJIAANQUANXISHU。

5.3 KONGQI(ZHENGQI)FANGMIAN

5.3.1 KONGQIXITONGDINGQIJIANCHA、QINGSAO、GENGHUANYUGUOLVQI,ZHONGGAOXIAOGUOLVQIXIN,FUYIXIANGYINGDEJIANCESHOUDUAN,SHIZHISHIZHONGBAOCHIXINGNENGLIANGHAOWENDING;DUIGAOXIAOGUOLVQIJINXINGGAOWENMIEJUNPINCIBUYIGUOGAO;GENGHUANGEGUOLVQIXINYINGJIZHONGWANCHENG,YIJIANSHAOKONGQIYALI、LIULIANGBUWENDINGZAOCHENGDERANJUNJIHUI;KAOLVQIHOUYINSU,GEGUOLVQIHEKONGQIGUANDAOSHANGDEPAIQIFAYINGBAOCHICHANGTONG,YIJISHUIERZISHENGZAJUN。

水果拉霸多人版 5.3.2 ZHENGQIZHILIANGDEBAOZHENGKANGSHENGSUSHIGUANMIEJUNYAOQIUZONGZHENGQIYALIBUDEDIYU0.400 Mpa,YIZHONGGUANLUMIEJUNSHIMODUANYALIBUDEDIYU0.250 Mpa。SHIGUANMIEJUNYAOQIUGELUJINQIYIJUGUANDAOCHICUN、ZHENGQIYALIJINLIANGZUODAOPINGHENG,BIJINQIBUJUN,GUANNEIJUBUWENDUBUTONGERYINGXIANGMIEJUNXIAOGUO。YAOGENJUBUTONGDEZHENGQILEIXING,ZONGJIEBUTONGDEMIEJUNFANGFA,SHIPEIYANGJIDEDAOLIANGHAODEMIEJUN。

6、JIEYU

RANJUNDETUJINGHEYUANYINSHIDUOFANGMIANDE,ZHURUDANGDIQIHOUBIANHUA,DANGDIKONGQIZHILIANG,SHEBEITIAOJIAN,SHEJIXITONGYINSU,GONGYITIAOJIAN,RENYUANZHIYESUZHIDENGDENG,KANGSHENGSUGONGZUOZHEHAIXUXUNQIUGENGDUODETUJINGLAIDADAOBIRANJUNDEMUDE。JUTONGJIYINQIFAJIAOGUANRANJUNDEYINSUJIQISUOZHANBIZHONGJIANBIAO1。

FENXIRANJUNYUANYINYEKECONGYIXIAFANGMIANPANDUAN:CONGRANJUNSHIJIANFENXI,FAJIAOZAOQIRANJUNKENENGYUANYINYOUZHONGZIDAIJUN、PEIYANGJIHUOSHEBEIMIEJUNBUCHEDI、YIZHONGCAOZUOBUDANG、KONGQIDAIJUNDENG;FAJIAOHOUQIRANJUNKENENGYUANYINYOUBULIAOSHIWURAN、SHEBEISHENLOU、CAOZUOWENTIDENG。CONGJUNXINGSHANGFENXI,RUORANYABAOGANJUN,KENENGSHIPEIYANGJIHUOSHEBEIMIEJUNBUCHEDI、KONGQIDAIJUNYINQI。CONGRANJUNGUIMOSHANGFENXI,RUODAMIANJIRANJUN,QIESUORANDESHITONGZHONGZAJUN,BANSHIKONGQIXITONGCHUXIANWENTI,RUOGEBIEGUANLIANXURANJUNBANSHISHEBEIWENTI。

ZONGERYANZHIKEFURANJUNSHIXIANGZHANGQIERFUZADEGONGZUO,YAOQIUSHENGCHANRENYUANJIYOUXIANGYINGDELILUNZHISHI,ZHANGWOMIEJUNDEYUANLI,YOUYOUFENGFUDESHIJIANJINGYAN,JIAOQIANGDEFENXIHEJIEJUEWENTIDENENGLI,TONGSHIYAODUOGUANZHUXIJIE,JIAYIZHONGSHICAINENGYOUXIAODEEZHIKANGSHENGSUSHENGCHANZHONGDERANJUNWENTI。

 

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文章标题:发酵罐染菌的途径及四大原因

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