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发酵罐设备到生物反应工程的发展融合

作者:发酵罐 时间:2018-03-26 09:37
发酵整个生物反应过程的关键设备。它是为特定的细胞或酶提供适宜的生长环境或进行特定的生化反应的设备,它的结构、操作方式和操作条件与产品的质量、产量和能耗有着密切的关系。发酵罐存在着物料的混合与流动、传热等化学工程问题; 信息摘要:
原始的手工作坊式的 发酵 制作凭借祖先传下来的技巧和经验生产发酵产品,体力劳动繁重,生产规模受到限制,难以实现工业化生产。于是,人们借鉴化学工程技术,对发酵生产工艺进行了规范,用泵和管道等输送方式替代了肩

发酵罐设备到生物反应工程的发展融合

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发酵罐设备到生物反应工程的发展融合

原始的手工作坊式的发酵制作凭借祖先传下来的技巧和经验生产发酵产品,体力劳动繁重,生产规模受到限制,难以实现工业化生产。于是,人们借鉴化学工程技术,对发酵生产工艺进行了规范,用泵和管道等输送方式替代了肩挑手提的人力搬运,以机器生产代替了手工操作,把作坊式的发酵生产成功地推上了工业化生产的水平。

在20世纪60年代初期,施工跨过公司决定研究生产微生物细胞作为饮料蛋白质的来源,推动了发酵技术的进步发展。由于微生物蛋白质的售价较低,所以比其他发酵产品的生产规模要求更大些。机械搅拌发酵罐的容积,已经扩大到150m³。由于发酵时对氧的需求量增加,不需要机械搅拌的高压喷射和强制循环的发酵罐应运而生。这种过程如果进行连续操作,则更为经济。连续发酵是向发酵罐中连续注入新鲜培养基,以促使微生物连续生长,并不断从中取出部分培养液。如ICI公司还在使用3000m³规模连续强制循环发酵罐,超大型的连续发酵的操作周期可超过100天。其问题是染菌的危害性已大大超过1940年代的抗生素生产。这类发酵罐的灭菌,是通过下列手段而达到的:即高度标准化的发酵罐结构、料液的连续灭菌和利用电脑控制灭菌和操作周期,以限度地减少人工操作的差错。但连续发酵的应用范围为有限,工业上普遍开始采用分批培养和分批补料培养法。

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文章标题:发酵罐设备到生物反应工程的发展融合

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